This is a research support post in Mishto lab within the Centre for Inflammation Biology and Cancer Immunology (CIBCI) at the Guy’s campus of King’s College London. This post could include experiments carried out at the Francis Crick Institute in Mishto lab.

 

The post aims to identify HLA-I epitopes and validate them with different techniques.

 

The successful candidate will be expected to lead, under the supervision of the group leader, a research whose principal aims are:

(i) discovery noncanonical (mutated) epitopes relevant in cancer immunotherapy.

(ii) isolating CD8+ T cell clones specific for HLA-I-restricted neoepitopes carrying recurrent driver mutations in cancer, and cloning their TCRs to investigate the epitope generation in cancer cells;

(iii) investigate the neoepitope antigenicity in peripheral blood of cancer patients.

 

Detailed knowledge of applied cellular and molecular biology and immunobiology, biochemistry and cloning would be highly advantageous.

 

This is a full time post (35 Hours per week), and you will be offered an a fixed term contract until 31/12/26