The School of Cardiovascular and Metabolic Medicine & Sciences (SCMMS), is one of six schools in the Faculty of Life Sciences & Medicine (FoLSM) at King College London. The School drives translation of world-leading basic science into advances in clinical practice in cardiac, vascular and metabolic medicine.  The School also hosts activities of the MRC/BHF Centre of Excellence for Advanced Cardiac Therapeutics (REACT) and the BHF Centre of Research Excellence at King’s.

 

Applications are invited for a talented and enthusiastic postdoctoral scientist to join Prof Mauro Giacca’s laboratory at the School of Cardiovascular and Metabolic Medicine & Sciences at King’s College London. The postholder will be part of a vibrant multi-disciplinary research group operating across different research themes in cardiac biology, having the specific aim to develop technologies for gene editing of cardiovascular inherited conditions.

 

In particular, the post-holder will develop CRISPR/Cas9- and Prime Editing-based methods for the corrections of DNA mutations leading to cardiomyopathy. This work will be performed in primary cardiomyocytes from human iPS cells, human myocardial slices from patients and humanised mouse models with the same mutations as patients, all of which are currently available in the laboratory.

 

Minimum qualifications are PhD and/or MD with expertise in molecular

and cellular biology and prior experience in gene editing, also for different applications.  Candidates should be highly motivated individuals with excellent communication skills, and have the ability to work independently. The post holder will have the opportunity to write and publish results of research studies in high impact score peer-reviewed journals and report research results at international conferences.

 

The post is based within the School of Cardiovascular and Metabolic Medicine & Sciences at the James Black Centre (King’s Denmark Hill campus) as part of the King’s College London BHF Centre of Research Excellence and the MRC/BHF Centre for Advanced Cardiac Therapeutics (REACT). The School and these Centres provide an outstanding highly multidisciplinary environment with state-of-the-art equipment, facilities and technical support for both laboratory work and animal studies.

 

The post is offered as a 1-year initial contract, with possibility of extension.